spermatogenesis is controlled by which hormone

PubMed Sertoli and germ cell development in hypogonadal (hpg) mice expressing transgenic follicle-stimulating hormone alone or in combination with testosterone. Spermatogenesis is a complex process involving mitotic cell division, meiosis and the process of spermiogenesis. 1985 Sep;12(3):531-55. Endocrinology 129(3):16141620, Gomez E, Morel G, Cavalier A, Lienard MO, Haour F, Courtens JL, Jegou B (1997) Type I and type II interleukin-1 receptor expression in rat, mouse, and human testes. Mice lacking FSH or its receptor are fertile, albeit with reduced germ cell numbers, and so this hormone is not an essential regulator of spermatogenesis but acts to optimise germ cell production Androgens also appear to regulate spermatogonial proliferation but, crucially, they are also required to allow spermatocytes to complete meiosis and form spermatids. Reprod Biol Endocrinol 1:52, Goddard I, Florin A, Mauduit C, Tabone E, Contard P, Bars R, Chuzel F, Benahmed M (2003) Alteration of lactate production and transport in the adult rat testis exposed in utero to flutamide. and transmitted securely. 1976;8(3):195-202. doi: 10.1111/j.1439-0272.1976.tb02135.x. A number of stages are involved, and its aim is the production of four haploid sperm cells from the diploid spermatogonium. Provided by the Springer Nature SharedIt content-sharing initiative, https://doi.org/10.1007/s00018-012-1079-1, access via Studies from rodent models suggest that gonadotropin hormones (both LH and FSH) support the process of spermatogenesis by suppressing the proapoptotic signals and thus promoting spermatogenic cell survival. Reprod Biol Endocrinol 4:51, Cederroth CR, Schaad O, Descombes P, Chambon P, Vassalli JD, Nef S (2007) Estrogen receptor alpha is a major contributor to estrogen-mediated fetal testis dysgenesis and cryptorchidism. Rev Reprod 4(1):3847, Tripathi R, Mishra DP, Shaha C (2009) Male germ cell development: turning on the apoptotic pathways. Spermatogenesis - an overview | ScienceDirect Topics Endocrinology 85(3):607609, Slaughter GR, Means AR (1983) Follicle-stimulating hormone activation of glycogen phosphorylase in the Sertoli cell-enriched rat testis. Please enable it to take advantage of the complete set of features! What are the male and female gonads? J Biol Chem. During the first spermatogenic cycle after puberty both FSH and androgen act to limit the massive wave of germ cell apoptosis which occurs at this time. Correspondence to Its presence in males is necessary for the maturation of spermatozoa. Duan M, Guo X, Chen X, Guo M, Xu H, Hao L, Wang C, Yang Y. Toxics. HHS Vulnerability Disclosure, Help Paracrine control of spermatogenesis Front Cell Dev Biol. Dev Growth Differ 46(4):327334, Clyde HR, Walsh PC, English RW (1976) Elevated plasma testosterone and gonadotropin levels in infertile males with hyperthyroidism. eCollection 2023. Infante D. Henrique, 6200-506, Covilh, Portugal, Marco G. Alves,Lus Rato,Slvia Socorro&Pedro F. Oliveira, CNC-UC, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517, Coimbra, Portugal, Department of Life Sciences, Faculty of Science and Technology (FCTUC), University of Coimbra, 3004-517, Coimbra, Portugal, Institute of Physiology, Faculty of Medicine, University of Coimbra, 3000-354, Coimbra, Portugal, You can also search for this author in Reproduction is controlled by the hormones functional in the hypothalamic-pituitary-gonadal (HPG) axis. MeSH The hormonal regulation of spermatogenesis involves a complex interplay within the hypothalamo-pituitary-testicular axis, which commences before birth with male sexual development and continues through puberty and into adulthood. Liu Z, Larsen M, Lei Z, Rao CV, Kumar TR. [Induction of spermatogenesis in hypogonadotrophic hypogonadism]. Unable to load your collection due to an error, Unable to load your delegates due to an error. and transmitted securely. Microsc Res Tech 72(8):552557, ODonnell L, Robertson KM, Jones ME, Simpson ER (2001) Estrogen and spermatogenesis. official website and that any information you provide is encrypted Spermatogenesis usually begins after the first or second molt. CAS Gan M, Jing Y, Xie Z, Ma J, Chen L, Zhang S, Zhao Y, Niu L, Wang Y, Li X, Zhu L, Shen L. Int J Mol Sci. 8600 Rockville Pike MeSH The other hormones/local factors which can regulate spermatogenesis include activins and estrogens although their role in normal physiological regulation of this process needs to be more clearly established. 1 and Table 1).These hormonal messengers are critical not only for regulation of male germ cell development, but also for the proliferation and . 2000 Jan;141(1):18-27. doi: 10.1210/endo.141.1.7276. Unable to load your collection due to an error, Unable to load your delegates due to an error. Possible role for interleukin-1, a putative intermediary in the ovulatory process. The site is secure. Epub 2021 Mar 17. government site. A full . Because there are no receptors for FSH or testosterone on germ cells, there are intermediate steps in this action, the nature of which are unknown. 2017 Feb 7;8(6):10714-10725. doi: 10.18632/oncotarget.12956. CH 28 - Hormonal Control of Spermatogenesis Flashcards Normal testicular function is dependent upon hormones acting through endocrine and paracrine pathways both in vivo and in vitro. Accessibility Price excludes VAT (USA) Hormonal regulation of spermatogenesis in the hypophysectomized rat: cell viability after hormonal replacement in adults after intermediate periods of hypophysectomy. Let us look at each stage of the spermatogenesis process in some detail. The https:// ensures that you are connecting to the Clipboard, Search History, and several other advanced features are temporarily unavailable. Harnessing male germline epigenomics for the genetic improvement in cattle. Accessibility and transmitted securely. Dev Biol. [Organization and regulation of spermatogenesis]. Fish spermatogenesis, from spermatogonial stem-cell renewal to sperm maturation, is controlled by the sex steroid hormones. From stage X onwards, these cells start to proliferate in such a way that the numbers of As and Apr spermatogonia remain relatively constant and more Aal spermatogonia are formed. The effects of hormonal changes on sperm DNA integrity in oligoasthenoteratospermia individuals: A case-control study. Epub 2014 Mar 2. Biol Reprod 47(5):823831, Syed V, Stephan JP, Gerard N, Legrand A, Parvinen M, Bardin CW, Jegou B (1995) Residual bodies activate Sertoli cell interleukin-1 alpha (IL-1 alpha) release, which triggers IL-6 production by an autocrine mechanism, through the lipoxygenase pathway. J Reprod Fertil 118(1):127135, Kreisberg RA (1980) Lactate homeostasis and lactic acidosis. Proc Natl Acad Sci USA 101(18):68766881, Holdcraft RW, Braun RE (2004) Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids. MeSH Endocr Rev 22(3):289318, Li H, Papadopoulos V, Vidic B, Dym M, Culty M (1997) Regulation of rat testis gonocyte proliferation by platelet-derived growth factor and estradiol: identification of signaling mechanisms involved. Role of Follicle-Stimulating Hormone in Spermatogenesis Spermatogenesis Flashcards | Quizlet In the male they concern the maintenance of testicular testosterone (T) production and spermatogenesis by the two pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Epub 2022 Sep 13. PMC Hormonal control of germ cell development and spermatogenesis 1823(8):13891394, Kaiser GR, Monteiro SC, Gelain DP, Souza LF, Perry ML, Bernard EA (2005) Metabolism of amino acids by cultured rat Sertoli cells. Triple-Hormone-Receptor Agonist Retatrutide for Obesity A Phase 2 2018 Jul 29;2018:7196142. doi: 10.1155/2018/7196142. Endocrinology 107(4):970976, Robinson R, Fritz IB (1979) Myoinositol biosynthesis by Sertoli cells, and levels of myoinositol biosynthetic enzymes in testis and epididymis. Int J Androl 34(6pt2):e612e620, Rato L, Alves MG, Socorro S, Carvalho RA, Cavaco JE, Oliveira PF (2012) Metabolic modulation induced by oestradiol and DHT in immature rat Sertoli cells cultured in vitro. FSH regulates the proliferation and maturation of germ cells independently and in combination with LH. Nature 258(5536):620622, De Gendt K, Swinnen JV, Saunders PT, Schoonjans L, Dewerchin M, Devos A, Tan K, Atanassova N, Claessens F, Lecureuil C, Heyns W, Carmeliet P, Guillou F, Sharpe RM, Verhoeven G (2004) A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. Spermatogenesis is completely dependent on the pituitary hormone follicle-stimulating hormone (FSH) and androgens locally produced in response to luteinising hormone (LH). Background: Human reproduction is regulated by the combined action of the follicle-stimulating hormone (FSH) and the luteinizing hormone (LH) on the gonads. Biol Reprod 79(1):2634, Odet F, Gabel SA, Williams J, London RE, Goldberg E, Eddy EM (2011) Lactate dehydrogenase C and energy metabolism in mouse sperm. Although the mechanisms by which SCs fulfill their own and germ cells metabolic needs are mostly studied in vitro, SC metabolism is unquestionably a regulation point for germ cell development and the hormonal control of these processes is required for a normal spermatogenesis. Mol Cell Endocrinol 182(2):175179, Zhou Q, Nie R, Prins GS, Saunders PT, Katzenellenbogen BS, Hess RA (2002) Localization of androgen and estrogen receptors in adult male mouse reproductive tract. Endocrinology 137(2):514521, Hoeben E, Van Aelst I, Swinnen JV, Opdenakker G, Verhoeven G (1996) Gelatinase A secretion and its control in peritubular and Sertoli cell cultures: effects of hormones, second messengers and inducers of cytokine production. J Membr Biol 227(1):4955, Leblond CP, Clermont Y (1952) Spermiogenesis of rat, mouse, hamster and guinea pig as revealed by the periodic acid-fuchsin sulfurous acid technique. 2023 May 18;2023(3):hoad022. Hormonal control of spermatogenesis - PubMed S R, Neves R, Fernandes S, Alves C, Carvalho F, Silva J, Cremades N, Malheiro I, Barros A, Sousa M. Biol Reprod. Soc Reprod Fertil Suppl 65:309325, Miki K, Qu W, Goulding EH, Willis WD, Bunch DO, Strader LF, Perreault SD, Eddy EM, OBrien DA (2004) Glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme, is required for sperm motility and male fertility. Meehan T, Schlatt S, O'Bryan MK, de Kretser DM, Loveland KL. Clipboard, Search History, and several other advanced features are temporarily unavailable. Careers. Overview of follicle stimulating hormone and its receptors in reproduction and in stem cells and cancer stem cells. J Androl 19(1):2130, Bremner WJ, Millar MR, Sharpe RM, Saunders PT (1994) Immunohistochemical localization of androgen receptors in the rat testis: evidence for stage-dependent expression and regulation by androgens. Mol Pharmacol 71(2):473482, Gupta G, Srivastava A, Setty BS (1991) Androgenestrogen synergy in the regulation of energy metabolism in epididymis and vas deferens of rhesus monkey. Spermatogenesis and folliculogenesis involve cell-cell interactions and gene expression orchestrated by luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Three hormones are the principle regulators of the male reproductive system: follicle-stimulating hormone ( FSH) stimulates spermatogenesis; luteinizing hormone (LH) stimulates the production of testosterone; and testosterone stimulates the development of male secondary sex characteristics and spermatogenesis. Hormonal control of spermatogenesis - ScienceDirect Cell. J Reprod Fertil 73(2):497503, Coniglio JG, Sharp J (1989) Biosynthesis of [14C]arachidonic acid from [14C]linoleate in primary cultures of rat Sertoli cells. Biosci Rep 32(1):6169, Mita M, Hall PF (1982) Metabolism of round spermatids from rats: lactate as the preferred substrate. Hormones such as testosterone, FSH and luteinizing hormone (LH) are known to influence the germ cell fate. Life Sci 69(8):977986, Schteingart HF, Meroni SB, Canepa DF, Pellizzari EH, Cigorraga SB (1999) Effects of basic fibroblast growth factor and nerve growth factor on lactate production, gamma-glutamyl transpeptidase and aromatase activities in cultured Sertoli cells. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). This process starts with the mitotic division of the stem cells located close to the basement membrane of the tubules. Endocrinology 151(5):23432348, Amory JK, Bremner W (2001) Endocrine regulation of testicular function in men: implications for contraceptive development. Endocrinology 114(1):240246, Oliveira PF, Alves MG, Rato L, Laurentino S, Silva J, Sa R, Barros A, Sousa M, Carvalho RA, Cavaco JE, Socorro S (2012) Effect of insulin deprivation on metabolism and metabolism-associated gene transcript levels of in vitro cultured human Sertoli cells. Int J Androl 14(3):223231, Hales DB (1992) Interleukin-1 inhibits Leydig cell steroidogenesis primarily by decreasing 17 alpha-hydroxylase/C17-20 lyase cytochrome P450 expression. Rev Reprod 5(2):8492, Carreau S, Delalande C, Galeraud-Denis I (2009) Mammalian sperm quality and aromatase expression. However, it is known that initiation of spermatogenesis occurs at puberty due to the interaction of the hypothalamus, pituitary gland, and Leydig cells. Nat Rev Urol 9:330338, Jutte NH, Grootegoed JA, Rommerts FF, van der Molen HJ (1981) Exogenous lactate is essential for metabolic activities in isolated rat spermatocytes and spermatids. GnRH is made in the hypothalamus and travels to the pituitary where it stimulates FSH and LH secretion. FSH and testosterone (T) secretion are essential for the successful completion of spermatogenesis. Life Cycle Exposure to Cyhalofop-Butyl Induced Reproductive Toxicity in Zebrafish. Epub 2019 Sep 1. FOIA Semin Reprod Med 27(2):149158, Flier JS, Underhill LH, Marshall JC, Kelch RP (1986) Gonadotropin-releasing hormone: role of pulsatile secretion in the regulation of reproduction. Biochem Biophys Res Commun 143(1):241247, Palmero S, Prati M, Bolla F, Fugassa E (1995) Tri-iodothyronine directly affects rat Sertoli cell proliferation and differentiation. The regulation of spermatogenesis involves both endocrine and paracrine mechanisms. Proc Natl Acad Sci USA 101(5):13271332, Chang C, Chen YT, Yeh SD, Xu Q, Wang RS, Guillou F, Lardy H, Yeh S (2004) Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells. The human male and female reproductive cycles are controlled by the interaction of hormones from the hypothalamus and anterior pituitary with hormones from reproductive tissues and organs. P.F. Learn more about Institutional subscriptions, 5-Aminoimidazole-4-carboxamide-1--d-ribofuranoside, 5 Adenosine monophosphate-activated protein kinase, Nicotinamide adenine dinucleotide phosphate-oxidase, Sharpe RM, McKinnell C, Kivlin C, Fisher JS (2003) Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood. Spermatogenesis - an overview | ScienceDirect Topics The .gov means its official. Lipids 24(1):8485, Huynh S, Oulhaj H, Bocquet J, Nouvelot A (1991) Metabolic utilization of linoleate and alpha-linolenate in cultured Sertoli cells. Fertil Steril 23(12):886893, Mishra DP, Shaha C (2005) Estrogen-induced spermatogenic cell apoptosis occurs via the mitochondrial pathway: role of superoxide and nitric oxide. This complex differentiation process from round cells to the highly specialized structure of spermatozoa is controlled by a large number of genes (up to 1500) affecting spermatogenesis, which is reflected in the large number of male sterile mutants (reviews: Lindsley and Tokuyasu, 1980; Hackstein et al., 2000 ). Am J Physiol Endocrinol Metab 297(4):E907E914, Leiderman B, Mancini RE (1969) Glycogen content in the rat testis from postnatal to adult ages. Inhibin is secreted by the Sertoli cells and acts to decrease the levels of FSH. Would you like email updates of new search results? J Clin Invest 99(9):22742283, Sakai Y, Yamashina S, Furudate S (2004) Developmental delay and unstable state of the testes in the rdw rat with congenital hypothyroidism. In humans, the requirement for high intratesticular testosterone (T) concentration in spermatogenesis remains both a dogma . Within the seminiferous tubules, only SCs possess receptors for some hormones rendering them major targets for the hormonal signaling that regulates spermatogenesis. Biol Reprod 59(6):14251432, Gerard N, Syed V, Bardin W, Genetet N, Jegou B (1991) Sertoli cells are the site of interleukin-1 alpha synthesis in rat testis. Academic Press, London, pp 411416, Griswold M, McLean D (2006) The Sertoli cell. J Clin Endocrinol Metab 93(5):18151819, Palmero S, Maggiani S, Fugassa E (1988) Nuclear triiodothyronine receptors in rat Sertoli cells. Biol Reprod 55(4):917922, Bone W, Jones NG, Kamp G, Yeung CH, Cooper TG (2000) Effect of ornidazole on fertility of male rats: inhibition of a glycolysis-related motility pattern and zona binding required for fertilization in vitro. Sertoli cells (SCs) have functions that reach far beyond the physical support of germ cells, as they are responsible for creating the adequate ionic and metabolic environment for germ cell development. Huang L, Zhang J, Zhang P, Huang X, Yang W, Liu R, Sun Q, Lu Y, Zhang M, Fu Q. iScience. Hormonal regulation of spermatogenesis and spermiogenesis. Biol Reprod 85(3):556564, Klip A, Tsakiridis T, Marette A, Ortiz PA (1994) Regulation of expression of glucose transporters by glucose: a review of studies in vivo and in cell cultures. HHS Vulnerability Disclosure, Help J Biochem 89(4):13091315, Grootegoed JA, Oonk RB, Jansen R, van der Molen HJ (1986) Metabolism of radiolabelled energy-yielding substrates by rat Sertoli cells. government site. PMID: 18406689 DOI: 10.1016/1043-2760 (94)00215-p An official website of the United States government. Elrashidy RA, Zakaria EM, Elmaghraby AM, Abd El Aziz REM, Abdelgalil RM, Megahed RM, Elshiech AA, Salama DEA, Ibrahim SE. Eur J Endocrinol 134(5):633638, Palmero S, Prati M, Barreca A, Minuto F, Giordano G, Fugassa E (1990) Thyroid hormone stimulates the production of insulin-like growth factor I (IGF-I) by immature rat Sertoli cells.

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