Mazzanti et al. Asian J. Androl. Reprod. The National Research Foundation of South Africa and the Senate Research Council of the University of the Western Cape funded this study. Biol. Chances are, you won't have to give up your green tea habit if you drink in moderation. Stress leads to increased levels of the hormone glucocorticoid, which can have a negative effect on the production of testosterone and sperm. Fluid intake and weight gain. Prevent. Creatinine remained unchanged in its serum level in the treated rats (Table 3; P>0.05). Read This Next And believe it or not, the same may hold true for cellphones, so keep them out of his pocket too. Chim. However, subtle structural changes observed in the reduced diameter and epithelial heights of the seminiferous tubule and increased spontaneous acrosome reaction needs further investigation to understand the implications on fertility outcomes. (2011). Biomarkers 11, 10251032 (2002). 1).Rats treated with green tea showed no change in the weekly weight gain compared to the control (P > 0.05), although the 2% green tea . Google Scholar. However, a transient reduction in body weight was observed at week 5 in the 5% treatment group and may be attributed to taste aversion and reduced food intake. Green tea catechins (especially EGCG) are responsible for the reduced body weight by decreasing the differentiation and proliferation of adipocytes during lipogenesis46. Takami et al. The thoroughly mixed samples were incubated at 37C for 2h and read at 765nm. Res. Furthermore, the histological sections of the treated kidney and liver depicted standard architecture compared to the control (Figs. Caffeine and L-theanine work together to improve mood, reaction time, attention, and memory. Overall, fluid intake in male rats exposed to green tea (2% or 5%) did not differ to the control group (Table (Table2; 2; P > 0.05). Production of F-actin during capacitation was shown to be crucial in the prevention of spontaneous acrosome reaction71. Tsirulnikov, E., Huta, Y. Green tea (Camellia sinensis) for the prevention of cancer. Final body and organ weights were noted. (a) Sperm concentration, (b) sperm vitality, (c) total motility, (d) progressive motility, (e) total static sperm, (f) acrosome reacted spermatozoa. However, a positive trend in the level of testosterone was observed in a dose-dependent manner (ANOVA-trend analysis, repeated measure: P=0.029). Reprod. Protective effect of epigallocatechin gallate, a major constituent of green tea, against renal ischemiareperfusion injury in rats. Updated on August 5, 2021 What is Tea? & El-Mahdy, M. A. Biochem. 47, 40094017 (1999). Epigallocatechin-3-gallate is absorbed but extensively glucuronidated following oral administration to mice. Green tea contains caffeine, a stimulant that boosts mood, energy levels, reaction time, and memory. Reproductive organ weights are used as indicators of reproductive toxicity57, and a reduction of testicular weight is a sensitive parameter for interpretation of male gonadal toxicity58. Repeated administration of green tea polyphenols (GTPs) (750mg/kg) caused a hepatic injury24. Correspondence to 2d) remained unchanged (P>0.05) in both treated groups. In line with the observed level of testosterone and similar to a previous study33, intake of green tea in this study did not alter the weight of testosterone dependent organs (testis, epididymis, seminal vesicles and prostate gland). Excess acid can lead to digestive issues including constipation, acid reflux, and nausea. All authors read and approved the final manuscript. & Tomlinson, B. The leaves of green tea contain 3040% polyphenols (which contains 80% flavonoids), fibres (26%), proteins (15%), lipids (27%), vitamins and minerals (5%), methylxanthines (34%) and pigments (12%)2,8. Awoniyi, D. O., Aboua, Y. G., Marnewick, J. Biol. Annu. 2. Opuwari, C. S. & Monsees, T. K. In vivo effects of Aspalathus linearis (rooibos) on male rat reproductive functions. Flavanol content was determined using (+) catechin as standard88 and expressed as mg catechin equivalent/ml of tea. Mohamadin, A. M., El-Beshbishy, H. A. Genet. Following the fixing and tissue processing of the testis, epididymis, kidney and liver, hematoxylin & eosin staining was utilised. Dermatol. The total weight gain of the rats remained unchanged after consumption of green tea for 52days (Table 2; P>0.05). Green tea extract can potentiate acetaminophen-induced hepatotoxicity in mice. 8 So-Called Sperm Killers: Should You Worry? - Everyday Health This study demonstrates that continuous and prolonged intake of aqueous extract of green tea improved sperm parameters, specifically sperm concentration and vitality, and appears to be safe in the rats. J. Nutr. The ideal temperature for sperm production is a few degrees lower than body temperature, which is why the testicles sit where they do, says Baratz. We investigated the effect of green tea on the male rat reproductive system as well as its safety. Pharmacol. In comparison to the findings of this study, a previous study showed that black tea increased sperm vitality, motility, the epithelial height of the cauda epididymis, kidney weight, as well as spontaneous acrosome reaction while decreasing the activities of AST and ALT and diameter and epithelial height of the seminiferous tubule75, however, an increased creatinine activity was observed. Dias, T. R. et al. & McDowell, J. Chromatographic separation and automated analysis of flavanols. Our study however, also showed no change in the serum FRAP after drinking green tea in vivo, which supports the findings of Maxwell & Thorpe42. Routinely consuming excessive amounts of caffeine from tea could contribute to chronic headaches. The Biomedical research ethics committee of the University of the Western Cape approved this study (registration No: 11/7/40) and all experiments were performed in accordance with relevant guidelines and regulations. conducted the experiments, performed the statistical analysis and drafted the manuscript. Therapeutic Role of Green Tea Polyphenols in Improving Fertility: A Higher protein or amino acid intake modulates renal hemodynamic by increasing renal blood flow and elevating intraglomerular pressure that results in an increased glomerular filtration rate (GFR) as as well an increased kidney volume and weight50. Green tea infusion improves cyclophosphamide-induced damage on male mice reproductive system. Unfermented teas have high polyphenolic content, with catechin derivatives, EGCG being the most abundant and powerful antioxidant13. J. Investig. Anal. Bar: 100m. Marklund, S. & Marklund, G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Here are 10 science-backed ways to boost sperm count and increase fertility in men. Mol. Pathol. 102, 37 (1994). conceptualised the study and revised the manuscript. ***p<0.0001 compared to the control. Leary, S. et al. J. Med. White tea consumption restores sperm quality in prediabetic rats preventing testicular oxidative damage. Bodyweight gain of animals in all groups increased progressively throughout treatment (Fig. 105, 121126 (1984). Reproductive toxicants are known to reduce the diameter and epithelial height of seminiferous tubule as well as impair spermatogenesis59,60,61. Green tea consumption increases sperm concentration and - PubMed Biomarkers 15, 24732476 (2006). The ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: the FRAP assay. Exposure to heat is known to affect sperm production. Saunas, hot tubs and even heated car seats are all culprits, but one of the most common sources of heat is laptops. Nutr. Awoniyi, D. O., Aboua, Y. G., Marnewick, J. L., Plesis, S. Du & Brooks, N. L. Protective effects of rooibos (Aspalathus linearis), green tea (Camellia sinensis) and commercial supplements on testicular tissue of oxidative stressinduced rats. Protective effects of green tea extract were also demonstrated against nephrotoxic agents in rats27,28,29. Even slightly overweight men with a BMI of 25 can have a 22 percent lower sperm count. Rameshrad, M., Razavi, B. M. & Hosseinzadeh, H. Protective effects of green tea and its main constituents against natural and chemical toxins: a comprehensive review. The possible explanation could be due to the differences in bioavailability of green tea, as bioavailability and transformation of EGCG, the predominant catechin in green tea, differs significantly between humans, mice and rats44. Green tea consumption increases sperm concentration and - Nature Food Chem. How Over Consumption Of Green Tea Affects Fertility Indian J. Physiol. Sperm concentration was represented as millions per millilitre (106/ml). Caffeine intake may have a negative impact on male fertility, including and testicular function, especially when used in excess and when found in sugary beverages like cola and energy drinks. Benzie, I. F. & Strain, J. J. J. Clin. 47, 469474 (1974). Biol. Briefly, samples were mixed with Tris-EDA-HCl buffer and pyrogallol (1:15:1) and incubated at 25C for 10min. Acrosome reaction was evaluated according to Larson & Miller102. B Biol. J. Hepatol. All chemicals except mentioned otherwise were obtained from Sigma Aldrich (St. Louis, MO, USA). Male infertility can be caused by low sperm production, abnormal sperm function or blockages that prevent the delivery of sperm. Our study demonstrated that the level of testosterone (which plays a crucial role in spermatogenesis) remained unchanged, even though, a trend to increased values was observed with increasing concentration of green tea. Dias, T. R., Alves, M. G., Casal, S., Silva, B. M. & Oliveira, P. F. The single and synergistic effects of the major tea components caffeine, epigallocatechin-3-gallate and l-theanine on rat sperm viability. Bar: 100m. Effect of white tea (Camellia sinensis (L.)) extract in the glycolytic profile of Sertoli cell. Nutr. Andrologia 46, 867877 (2014). Toxins and contaminants make their way from the lungs through the circulatory system to the testicles, says Baratz. Effect of consumption of aqueous extract of green tea for 52days on the testes of male Wistar rats. Google Scholar. Fitoterapia 90, 151159 (2013). What about using a laptop? Green tea may help balance insulin in some people by improving the body's response to the hormone, although the potential effects of green tea extract on insulin resistance . Research has shown that moderate caffeine consumption has no negative influence on sperm count or quality, but reasonable consumption is 300 milligrams, or only about two cups of coffee, says Caitlin Dunne, a fertility doctor at the Pacific Centre for Reproductive Medicine in Vancouver. 10, 173171732217322 (2011). Furthermore, case-reports have associated the use of concentrated green tea-based supplements with liver toxicity in humans54,55. 28, 5663 (1957). Int. Does Caffeine Affect Fertility? - Verywell Family 3). Am. Effects of repeated green tea catechin administration on human cytochrome P450 activity. In normal cell biology, ROS levels increase with a decreasing antioxidant response, resulting in oxidative stress which threatens sperm biology. Opuwari, C. S. & Monsees, T. K. In vivo effects of black tea on the male rat reproductive system and functions of the kidney and liver. How Matcha Green Tea Works on Hormones, Endocrine Function, Does Matcha In this article, I hope to take you through the fertility benefits of green tea. Conversely, other contributions suggested a negative effect of cola-containing beverages and caffeine-containing soft drinks on semen volume, count and concentration. J. One unit is the amount of enzyme that inhibited the oxidation of pyrogallol by 50%, and the result represented as units per milligram of protein. 58, 29612970 (2019). Previously frozen testis (20% w/v), kidney (20% w/v), and liver (20% w/v) tissues were swiftly thawed and homogenised with PRO 200 homogeniser (Proscientific Inc, Oxford, USA), in 1ml ice-cold Tris-buffered saline (TrisHCl 20mM, NaCl 150mM, pH 7.4) and centrifuged (5,000g, 30min and 4C). 3, 383392 (2007). Salminen, W. F. et al. CAS We further identified that the lifespan extension properties of green tea was only observed in the presence of females which alludes to a reproductive (or mating) dependent mechanism. Medicinal and therapeutic potentialities of tea (Camellia sinensis L.): a review. A 2017 study in Nutrition Journal revealed that men who drink more than four cups of coffee a day have a higher proportion of abnormally shaped sperm. increases the total number of motile sperm. Trans fats may also have a negative impact on the duration of pregnancy, resulting in preterm labor and birth. 3, 47 (2014). Its also worth noting that certain occupations that involve heat, such as working as a chef in a hot kitchen or as a firefighter in a non-breathable uniform, can have a negative effect on sperm count. Supplementation of sperm storage media with tea extract increased sperm viability in a dose-dependent manner1. Bar: 100m. Beneficial effects of green tea: A literature review - PMC Drinking a Lot of Green Tea Could Mess with Your Fertility In brief, sperm samples were fixed with 4% p-formaldehyde in PBS (1:5) for 5min and centrifuged (3,000g, 3min). Rusak, G., Komes, D., Liki, S., Hori, D. & Kova, M. Phenolic content and antioxidative capacity of green and white tea extracts depending on extraction conditions and the solvent used. Effect of green tea and its polyphenols on mouse liver. Reprod. Nephrol. Sci Rep 10, 15269 (2020). Serum ALT activity decreased significantly in the treated groups (Table 3; P>0.05). Sperm motility was determined by placing sperm suspension (5l) in a Leja slide (Leja Products B.V., Nieuw Vennep, Netherlands) and evaluated with Sperm Class Analyzer software (Microptic, Barcelona, Spain). The authors declare no competing interests. Cochrane Datab. Smoking either tobacco or marijuana may reduce sperm count, efficacy and quality, says Baratz. Tea association of the USA, Inc. Shivashankara, A. R. et al. Mahmoud, M. F., Fahmy, A. HPLC-MSn analysis of phenolic compounds and purine alkaloids in green and black tea. 1. Low doses of GTPs (0.01 and 0.1%) but not the high dose of GTPs (1%) ameliorated dextran sulfate sodium (DSS) increased ALT and AST levels in mice22. Philos. Food Res. After that, the supernatants stored at 80C and used for antioxidant and biochemical assays. Not ejaculating enough It's a misconception that men have to save up sperm when it's baby-making time. Green tea also improves metabolism and weight loss. After that, contents were briskly shaken out and rinsed three times with diluted wash solution (400l) and stricken sharply on absorbent paper to remove residual droplet. Isotani, A. et al. Testosterone Side Effects of Green Tea | livestrong White tea as a promising antioxidant medium additive for sperm storage at room temperature: a comparative study with green tea. Besides, 2% and 5% green tea caused no change in the weight of the testis, epididymis, prostate, seminal vesicles and liver on the male rats (Table 2; P>0.05), while a substantial rise in the weight of the kidney was observed following exposure to 5% green tea (Table 2; P<0.05). Clin. The animals were kept under standard conditions in a room at a temperature of 2124C with a constant 12h light/dark cycle. 5, 5157 (2009). These are suggestive of possible effects of the antioxidants in these plants on various aspects of male reproductive functions. This is a fact. Toxicol. (2007). Overall, they included 19,967 men. Toxicol In Vitro 41, 214222 (2017). J. It may be surprising, but all teas including black, green, oolong, and white tea come from the same plan, Camellia sinensis, which is a sub-tropical, evergreen plant native to Asia but is now grown around the world. Am. Department of Pre-Clinical Sciences, University of Limpopo, Polokwane, South Africa, Department of Medical Biosciences, University of the Western Cape, Cape Town, South Africa, You can also search for this author in Biochem. One thing that can help reverse damage to "Old Eggs" - green tea Effect of consumption of aqueous extract of green tea for 52days on the cauda epididymis of male Wistar rats. & Brooks, N. The effects of rooibos (Aspalathus linearis), green tea (Camellia sinensis) and commercial rooibos and green tea supplements on epididymal sperm in oxidative stress-induced rats. The good taste of this tea also attracts people to consume it. Drug Saf. The amount of daily intake of fluid and the weekly bodyweight of the animals were recorded. Food Sci. J. Further analysis of the antioxidant capacity of green tea in vitro, using FRAP showed a concentration-dependent increase; however, it remained unchanged in the serum of the treated male rats.
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does green tea affect male fertility